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People with Down syndrome may hold the key to treating Alzheimer’s
disease in its earliest stages, according to a UC Irvine medical study
released Monday.
The study, which was conducted on patients with Down syndrome who died
with Alzheimer’s disease, shows that the earliest brain changes of
Alzheimer’s may be seen in childhood. It also indicates that antioxidants
could possibly be used to help prevent or slow the development of the
disease in people with Down syndrome and the general population.
Ira Lott, professor of pediatrics and neurology; Elizabeth Head,
research scientist at UCI’s institute of Brain Aging and Dementia; and
their colleagues found that an oxidized version of a key protein linked
to Alzheimer’s was found in the brains of young deceased patients with
Alzheimer’s.
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